A team of scientists headed by Rosalind Franklin University Professor David M. Mueller, PhD, has solved the structure of mitochondrial ATP synthase, an enzyme that makes ATP, adenosine triphosphate, ...

ATP, the fuel of life, is produced in mitochondria of living cells by a molecular machine, the ATP synthase. We have isolated the machines from four fungal species, compared their stabilities and ...

Found inside mitochondria, ATP synthase generates the energy storage molecule adenosine triphosphate, which the cells of all living things use for fuel. The enzyme generally looks similar in shape ...

In 2005, a class of compound was discovered that could inhibit the bacterium that causes tuberculosis infections in humans — Mycobacterium tuberculosis 1. Unexpectedly, the target of these drugs was ...

Rotary ATPases are ubiquitous membrane-bound macromolecular enzymes with similar architecture and mechanism but two distinct physiological functions. All rotary ATPases consist of a transmembrane ...

The way a key cellular motor works at an atomic level has been uncovered by simulations conducted by RIKEN biophysicists.

Mitochondrial dysfunction, including decreased mitochondrial respiration and increased mitochondrial stress, is associated with many major human diseases and casual to many pathological defects.

The chemical ATP, adenosine triphosphate, is the fuel that powers all life. Despite ATP's central role, the structure of the enzyme generating ATP, F1Fo-ATP synthase, in mammals, including humans, has ...

Oncotarget recently published "Targeting breast cancer metabolism with a novel inhibitor of mitochondrial ATP synthesis" by Kim, et al. which reported that the authors show that CADD522 inhibits ...

Scientists have solved the structure of mitochondrial ATP synthase, an enzyme that makes ATP, adenosine triphosphate, the major energy source of cells. A team of scientists headed by Rosalind Franklin ...