Depression is a complex and deeply personal experience. While almost everyone has periods of sadness, low mood or grief, depression is different. Major depressive disorder is persistent, interferes ...

In the intricate chemical symphony of the brain, glutamate stands as the principal conductor. As the brain's most abundant excitatory neurotransmitter, glutamate facilitates our ability to learn, form ...

Since the 1960s, researchers have postulated that major depression stems from disruptions in the serotonin neurotransmitter system, but the evidence for that idea, though plentiful, was indirect. In ...

Depression has often been blamed on low levels of serotonin in the brain. That answer is insufficient, but alternatives are coming into view and changing our understanding of the disease. The ...

Depression is a complex condition correlated with multiple differences in brain function and mechanisms. A new paper spanning known data about the neurotransmitter GABA and its principal receptors ...

Drugs that target the neurotransmitter serotonin have long been prescribed to treat depression. Now the spotlight is turning to other aspects of brain chemistry. In this episode, the ...

A new study highlights the link between inflammation and depression, challenging traditional neurotransmitter-focused theories. An examination of decades of research suggests that immune system ...

Researchers are testing whether drugs designed to quiet the immune system can lift severe depression that resists ...