The use of tryptase and tryptase genotyping assessments is revolutionizing the screening, diagnosis, and management of systemic mastocytosis (SM). Here’s a comprehensive review and update. A Serious ...

The SM treatment market offers opportunities through targeted therapies e.g., tyrosine kinase inhibitors, driven by aging ...

Advanced systemic mastocytosis is a progressive disorder that causes the atypical buildup of mast cells in different organs in the body. Treatment aims to slow the progression of the condition and ...

Credit: Getty Images. The sNDA is supported by data from the phase 2 PIONEER trial that evaluated the efficacy and safety of avapritinib in patients with indolent systemic mastocytosis. The Food and ...

Treatment with Ayvakit was associated with promising outcomes in patients with mastocytosis, according to findings from the PIONEER trial. Ayvakit (avapritinib) improved outcomes for patients with non ...

Dana-Farber Cancer Institute researchers are breaking new ground in the fight against systemic mastocytosis, a rare and heterogeneous condition that is often challenging for clinicians to accurately ...

The National Institute for Health and Care Excellence has recommended avapritinib (Ayvakyt) as a treatment option for adults with advanced systemic mastocytosis. Mastocytosis is a rare group of ...

Advanced systemic mastocytosis (advSM) is a rare and serious form of systemic mastocytosis, a blood disorder that involves the overproduction of mast cells. Mast cells are a type of white blood cell ...

-- Bone density analyses reported in patients with advanced SM underscore disease-modifying effects of AYVAKIT -- "Systemic mastocytosis is associated with mast cell infiltration across multiple organ ...

Communicating effectively with other specialists on the care team is essential, says Aaron T. Gerds, MD, MS, Associate Professor of Medicine at Cleveland Clinic Lerner College of Medicine of Case ...

Systemic mastocytosis is a myeloid neoplasm divided into six subcategories by the recent classification by WHO. It involves the accumulation of abnormal mast cells (MCs) in the skin, liver, spleen, ...