Targeted genome editing is a broadly applicable approach for efficiently modifying essentially any sequence of interest in living cells or organisms. This technology relies on the use of engineered ...

TALENs involve the synthesis of the C-terminal with type II restriction enzyme, Fokl, in order to produce heterodimers that form a double-stranded break (DSB) in DNA. Recent advancements in TALEN ...

The FLASH system is a rapid and cost-effective method for large-scale assembly of transcription activator-like effector nucleases. Success and failure stories associated with gene editing approaches ...

However, how these regions corresponded to specific sequences of DNA remained elusive. Plant scientists suspected that understanding this mechanism could help identify targets during disease ...