Chromatin-remodeling enzymes perform the formidable task of reorganizing the structure of a stable macromolecular assembly, the nucleosome. Recently published work demonstrates that the SNF2H ...

This is a preview. Log in through your library . Abstract The effect of hyperthermia (40-48°C) on the nucleosome structure of mammalian chromatin was determined using the enzyme micrococcal nuclease.

In eukaryotes, DNA is tightly wound into a complex structure called chromatin. The basic packaging unit of DNA is the nucleosome core, consisting of 147 bp of DNA tightly wrapped around a histone ...

Proceedings of the National Academy of Sciences of the United States of America, Vol. 78, No. 11, [Part 2: Biological Sciences] (Nov., 1981), pp. 6803-6807 (5 pages) Switches of the types of histones ...

Tokyo, April 14 - A research group led by Hitoshi Kurumizaka, a professor of structural biology at Waseda University, unveiled the crystal structure of an overlapping dinucleosome, a newly discovered ...

Illustration of H2B or H3 tail-less nucleosomes. Nucleosomes lacking H2B and H3 tails exhibit weakened interactions between histone tails and nucleosomal DNA, leading to less stable nucleosome ...

It takes a lot of packaging to squeeze DNA into the nucleus of a cell. The DNA in our chromosomes is packaged into nucleosomes, which consist of about 150 DNA base pairs wrapped around eight-protein ...

Researchers discovered that stiff DNA segments inside nucleosomes physically block chromatin remodeling. The remodeling machinery normally shifts DNA by creating 20–30 base-pair loops, but these ...

Two scientists at the Johns Hopkins University School of Medicine have unraveled aspects of how DNA organizes and preserves genetic information. Newly published research by Cynthia Wolberger, Ph.D., ...

Researchers at The University of Texas MD Anderson Cancer Center have shown that DNA inflexibility, or rigidity, inside the nucleosome regulates the positioning of INO80. This highlights that the ...

Researchers at The University of Texas MD Anderson Cancer Center have shown that DNA inflexibility, or rigidity, inside the nucleosome regulates the positioning of INO80. This highlights that the ...